Inquiry

First Name *

Last Name *

Business Email *

Phone

Company/Institution

Job Title

Services or Products of Interest *

When do you expect your project to start?

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Prunin

Inquiry

Specification

Cat. No.

SMD1105

Related Diseases

Depression

Product Name

Prunin

Size

1.0mg; 5.0mg; 10.0mg

Price

Inquiry

Availability

2 Weeks

Description

Prunin is a polyketide synthase-derived flavonoid glycoside that has been found in G. glabra and has diverse biological activities. It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively). Prunin (2 µM) scavenges DPPH radicals in a cell-free assay. It inhibits the activity of protein tyrosine phosphatase 1B (PTP1B; IC50 = 5.5 µM for the human enzyme) and increases insulin-induced glucose uptake in insulin-resistant HepG2 hepatocellular carcinoma cells in a concentration-dependent manner. Prunin inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells.

CAS Number

529-55-5

Chemical Formula

C21H22O10

Exact Mass

434.1213

Molecular Weight

434.397

Elemental Analysis

C, 58.06; H, 5.11; O, 36.83

Synonym

Prunin; Naringenin 7-O-β-D-glucopyranoside; Naringenin 7-O-glucoside; NSC 135064; NSC-135064; NSC135064;

IUPAC/Chemical Name

(S)-5-hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one

InChi Key

DLIKSSGEMUFQOK-SFTVRKLSSA-N

InChi Code

InChI=1S/C21H22O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-6,14,16,18-24,26-28H,7-8H2/t14-,16+,18+,19-,20+,21+/m0/s1

SMILES Code

OC1=C2C(O[C@H](C3=CC=C(C=C3)O)CC2=O)=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@@H]([C@H]4O)O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.