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Saredutant

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Specification

Cat. No.

SMD1139

Related Diseases

Depression

Product Name

Saredutant

Size

Customizable

Price

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Description

Saredutant, aslo known as SR-48968, is a NK2 receptor antagonist for the treatment of major depressive disorder. Saredutant has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant, ameliorates stress-induced conditions without impairing cognition. SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.

CAS Number

142001-63-6

Chemical Formula

C31H35Cl2N3O2

Exact Mass

551.2106

Molecular Weight

552.54

Elemental Analysis

C, 67.39; H, 6.39; Cl, 12.83; N, 7.61; O, 5.79

Synonym

SR-48968; SR489686; SR 489686; Saredutant

IUPAC/Chemical Name

(S)-N-(4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)-N-methylbenzamide

InChi Key

PGKXDIMONUAMFR-AREMUKBSSA-N

InChi Code

InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1

SMILES Code

O=C(N(C[C@@H](CCN1CCC(C2=CC=CC=C2)(NC(C)=O)CC1)C3=CC=C(Cl)C(Cl)=C3)C)C4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.