Sucrose Preference Test to Measure Anhedonic Behaviour in Mice

The sucrose preference test (SPT) is a reward-based test, used as in indicator of anhedonia. Reduced preference for sweet solution in SPT represents anhedonia, while this reduction can be reversed by treatment with antidepressants.

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Accurate Quantification of Pleasure Deficit: The One-stop Sucrose Preference Test (SPT) Standardized Protocol

Why does this protocol enhance your research productivity?

Targeting the Core Symptoms of Depression:

The sucrose preference test is the gold-standard behavioral paradigm for assessing anhedonia. By quantifying the reduced preference for sucrose solution in mice, it mimics the core pathological feature of "loss of pleasure" in human depression, providing critical phenotypic evidence for antidepressant efficacy evaluation.

Standardized Operational Guidelines for The Entire Process

Provides materials and reagents, experimental equipment and detailed operation procedures for sugar-water preference experiments.

Data Visualization and Analysis

Core index: Sucrose preference (%) = Sucrose water consumption / (Sucrose water + Purified water consumption) x 100%.
Depression phenotypic criterion: preference <40% or significantly lower than control (*p* < 0.05).

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Sucrose Preference Test to Measure Anhedonic Behaviour in Mice

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