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Vestipitant

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Specification

Cat. No.

SMD1313

Related Diseases

Insomnia

Related Diseases

Anxiety

Product Name

Vestipitant

Size

Customizable

Price

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Description

Vestipitant, also known as GW597599, is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) receptor blockade in the alleviation of anxiety and, possibly, depression. It is under development as a potential antiemetic and anxiolytic drug, and as a treatment for tinnitusand insomnia.

CAS Number

334476-46-9 (free base)

Chemical Formula

C23H24F7N3O

Exact Mass

491.18076

Molecular Weight

491.44

Elemental Analysis

C, 56.21; H, 4.92; F, 27.06; N, 8.55; O, 3.26

Synonym

GW597599; GW 597599; GW-597599; Vestipitant

IUPAC/Chemical Name

(2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide

InChi Key

SBBYBXSFWOLDDG-JLTOFOAXSA-N

InChi Code

InChI=1S/C23H24F7N3O/c1-13-8-18(24)4-5-19(13)20-12-31-6-7-33(20)21(34)32(3)14(2)15-9-16(22(25,26)27)11-17(10-15)23(28,29)30/h4-5,8-11,14,20,31H,6-7,12H2,1-3H3/t14-,20-/m1/s1

SMILES Code

O=C(N1[C@@H](C2=CC=C(F)C=C2C)CNCC1)N([C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.