Unlocking Key Models for Depression Research: Chronic Unpredictable Mild Stress (CUMS) Rat Model

This exclusive case study reveals Ace Therapeutics' validated CUMS model, designed to accelerate your antidepressant drug development by simulating human-relevant depressive phenotypes in rats.

Key Insights You' ll Discover

Human-Mimetic Stress Modeling

Precisely replicates stressors (e.g., circadian disruption, cold swim, foot shock) to induce robust depressive phenotypes in 4 weeks – mirroring complex human etiology.

Triple-Validation Efficacy Assessment

Combines behavioral metrics (sucrose preference, forced swim immobility), neuroanatomical analysis (hippocampus), and serum biomarkers for comprehensive MOA profiling..

Standardized Molding Process

Step-by-step workflow from baseline screening to endpoint analysis:

• Rigorous Design: 50 male rats (220-250g) across 6 cohorts including ketamine control
• Stressor Schedule: 1-3 randomized interventions/day with quantitative severity control
• 3-Phase Evaluation: Pre-modeling → Post-CUMS → Post-treatment

Critical Data Highlights

Behavioral Dysfunction Quantification

• Decrease in sucrose preference index (marker of dysphoria)
• Increased immobility time in forced swim test

Translational Biomarker Profiling

Hippocampal integrity + serum corticosterone/BDNF levels correlated with behavioral recovery

Dose-Response Validation

High-sensitivity detection of test compound effects across low/medium/high IV doses vs. ketamine benchmark

Download Now to Access

• Full stressor implementation timeline
• Behavioral testing SOPs with QC thresholds
• Statistical analysis criteria for efficacy claims
• Technical consultation contact

Elevate your antidepressant drug pipeline with CUMS rat models widely cited in peer-reviewed studies.

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