Groundbreaking Study Reveals: Novel Evidence on Inflammatory

Depression Mechanisms and Pharmacological Interventions

Download the Full Experimental Protocol to Obtain Key Research Data for Antidepressant Drug Development

Development of High-Relevance Model

• Intraperitoneal injection of LPS (0.5 mg/kg) induced depression-like behaviors in mice.
• Activation of the innate immune system accurately recapitulated human pathology of inflammation-associated depression.
• Significant induction of classic behavioral alterations, including decreased locomotor activity and anhedonia, was observed.

Validation of Fluoxetine Efficacy

• Treatment with FLU (10 mg/kg) significantly ameliorated LPS-induced behavioral deficits.
• Efficacy is confirmed through dual behavioral paradigms: the Forced Swim Test (FST) and Open Field Test (OFT).

Standardized Experimental System

• Male C57BL/6J mice (6-8 weeks old) are maintained under strict inbred strain control.
• A standardized protocol is implemented: from modeling → drug administration → behavioral phenotyping.
• Three experimental groups are designed: naïve control / LPS model / LPS+FLU treatment.

Download the Full Report Now

• Learn about peer-reviewed approaches to building depression models.
• Get key metrics for preclinical evaluation of antidepressant drugs.
• Accelerate your new drug development process.

You might be interested in...