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SB-228357

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Specification

Cat. No.

SMD1170

Related Diseases

Depression

Product Name

SB-228357

Size

10.0mg; 50.0mg

Price

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Availability

2 Weeks

Description

SB-228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). SB-228357 displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function.

CAS Number

181629-93-6

Chemical Formula

C22H17F4N3O2

Exact Mass

431.1257

Molecular Weight

431.39

Elemental Analysis

C, 61.25; H, 3.97; F, 17.62; N, 9.74; O, 7.42

Synonym

SB-228357; SB 228357; SB228357.

IUPAC/Chemical Name

1H-Indole-1-carboxamide, N-(3-fluoro-5-(3-pyridinyl)phenyl)-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-

InChi Key

RRJLJKRFFRZRAF-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)

SMILES Code

O=C(N1CCC2=C1C=C(C(F)(F)F)C(OC)=C2)NC3=CC(C4=CC=CN=C4)=CC(F)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.