BBB Damage

The BBB plays a crucial role in maintaining the homeostasis of the brain by regulating the transport of molecules and ions between the blood and the brain. BBB pathway antibodies provide researchers with an opportunity to better understand the major mediators and molecular mechanisms involved in BBB disruption, thus identifying potential targets for therapeutic intervention. For example, specific BBB pathway antibodies such as astrocyte aquaporin-4 and MMP antibodies, help researchers study the role of astrocytes and matrix metalloproteinases in BBB integrity and function.

Please access our full range of BBB damage-related antibodies for stroke research or contact our scientist for personalized assistance.

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1. Qin C, Yang S, Chu YH, et al. Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2022, 7(1):215.
2. Yang C, Hawkins KE, Doré S, et al. Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol. 2019, 316(2):C135-C153.
3. Nian K, Harding IC, Herman IM, et al. Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction. Front Physiol. 2020, 11:605398.