Metabotropic Receptor Antibodies

Ace Therapeutics is committed to supplying high-quality metabotropic receptor antibodies for stroke research to our clients at cost-effective prices. By collaborating with leading scientists and researchers, we have developed a comprehensive range of antibodies targeting various metabotropic receptors involved in stroke pathology. These antibodies are rigorously validated, ensuring specificity, sensitivity, and reproducibility in different experimental applications.

Metabotropic receptors are a subtype of membrane receptors that typically utilize signal transduction mechanisms (usually G proteins) and second messenger chemicals to activate a cascade of intracellular events. These intracellular events may include activation of protein kinases, opening or closing of ion channels, release of intracellular calcium ions, etc. Activation of metabotropic receptors can trigger various biochemical reactions in cells, thereby affecting physiological processes of cells, such as cell proliferation, differentiation, signal transduction, etc.

Ace Therapeutics's catalog of metabotropic receptor antibodies includes but is not limited to, mGluR1, mGluR5, and GABABR1. Although these metabotropic receptors do not directly affect the occurrence and development of stroke, they play an important role in neuroprotection and repair after stroke.

• mGluR1 and mGluR5 are glutamate metabotropic receptors, involved in the regulation of neuronal excitation and synaptic plasticity. Their activation can promote synapse formation and enhance communication between neurons, thereby helping to restore damaged neural network function after stroke.
• GABABR1 is a γ-aminobutyric acid-type metabotropic receptor, involved in signaling of the inhibitory transmitter γ-aminobutyric acid. Its activation can reduce the release of excitatory neurotransmitters, thereby balancing neuronal excitation and inhibition, helping to alleviate excitatory synaptic imbalance and neuronal damage after stroke.

In addition, these metabotropic receptors also play important roles in the regulation of inflammation and oxidative stress. Stroke will lead to an increase in inflammatory response and oxidative stress, and activation of mGluR1, mGluR5, and GABABR1 can inhibit the release of inflammatory mediators and the generation of oxidative stress, thereby helping to reduce cell damage caused by stroke.

Please access our all-series metabotropic receptor antibodies or contact our scientist for personalized assistance.