Dense-Core Vesicles Antibodies

Dense core vesicles (DCVs), a neuronal organelle, play a vital role in the neurotransmission process, which transport a variety of substances important for neuronal growth and function, such as neuropeptides, monoamines, and neurotrophic factors. Ace Therapeutics is committed to supplying high-quality DVC antibodies for stroke research to our clients at cost-effective prices. We have developed advanced techniques to produce antibodies specifically targeting DVCs, ensuring exceptional specificity and sensitivity in your experiments.

DCVs, also known as secretory vesicles or secretory granules, are specialized vesicles that are involved in the secretion of various molecules. They are predominantly found in neuronal cells, particularly in the axon terminals. Once neuronal stimulation, these vesicles fuse with the cell membrane, allowing the contents to be released into the synapse, where they can then interact with receptors on neighboring cells.

Release of neurotransmitters from secretory vesicles into the synaptic cleft occurs via exocytosis. When an action potential reaches the presynaptic terminal, it triggers the opening of voltage-gated calcium channels, causing an influx of calcium ions into the neuron. An increase in intracellular calcium concentration triggers the fusion of vesicles with the presynaptic membrane. When the vesicle fuses with the membrane, neurotransmitter molecules are released into the synaptic cleft. Calcium influx is a key regulator of vesicle fusion and neurotransmitter release. Different neurons may contain different types of secretory vesicles, each containing different neurotransmitters.

Ace Therapeutics offers a comprehensive catalog of products for studying DCVs, including but not limited to synaptophysin antibodies, Rab5 antibodies, VAMPA 1antibodies, SNAP25 antibodies, and their corresponding ELISA kits. Please access our all-series DVCs antibodies or contact our scientist for personalized assistance.