Vascular Mechanisms

Stroke involves thrombosis and vascular rupture due to a sudden interruption in the blood supply to the brain. Signal channels involved in thrombosis and a blood vessel in the brain tears or bursts include various factors, such as tissue factors, coagulation factors (such as thrombin), platelet activation factors, such as ADP and thromboxane, and endothelial cell dysfunction factors. These factors interact to promote blood clot formation or rupture of the vessel itself in the brain causing a stroke. By monitoring the levels and activity of antibodies associated with thrombosis and vessel rupture, research can better assess a patient's stroke risk and initiate appropriate interventions, as well as develop new strategies for thrombolysis.

Vascular Mechanisms

Please access our full range of vascular mechanisms-related antibodies for stroke research or contact our scientist for personalized assistance.

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Antibodies for Stroke Research

  1. Qin C, Yang S, Chu YH, et al. Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2022, 7(1):215.
  2. Sierra C, Coca A, Schiffrin EL. Vascular mechanisms in the pathogenesis of stroke. Curr Hypertens Rep. 2011,13(3):200-7.
  3. Liu J, Wang Y, Akamatsu Y, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014, 115:138-56.
  4. Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood. 2008, 112(9):3555-62.
  5. Li Z, Bi R, Sun S, et al. The Role of Oxidative Stress in Acute Ischemic Stroke-Related Thrombosis. Oxid Med Cell Longev. 2022, 2022:8418820.
All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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