Development of Stem Cellular Therapy for Stroke

Targeting stroke to develop stem cell therapies is a hot direction at present. Much data have shown that stem cell therapy is a potentially effective pathway for subacute and chronic stroke. Stem treats stroke through two main pathways: cell differentiation and secretion of paracrine factors, Ace Therapeutics provides comprehensive preclinical research services, from screening for appropriate stem cell types to safety evaluation, to promote the development of your stem for stroke.

Stem Cell Bank

The first step in developing stem cell therapies for stroke is to screen for the appropriate stem cell type, which can notably affect the outcome of stem . Ace Therapeutics has an extensive cell bank covering the types of stem cells that can be used to develop stem cell therapies, including but not limited to adult tissue-derived stem cells (neural stem cell, mesenchymal stem cells), adipose tissue-derived MSCs, breastmilk-derived stem cells, and menstrual blood stem cells. Based on our stem cell bank, our expert scientists will select the most suitable type of stem cells for you based on both the experiment and stem cells.

Stem Cell Characterization & Expansion

Although stem cells may have the capacity for "immortal" renewal, the alteration of stem cell status and genetic material by in vitro culture can seriously affect the outcome of stem . Therefore, proper characterization and expansion of stem cells is a critical step in ensuring the development of your > for stroke.

• Ace Therapeutics provides stem cell identification services to confirm the cellular properties, pluripotency, gene expression, safety, and other characteristics of stem cells, including pluripotency marker assay, genetic test, cancer susceptibility test, differential chemistry test, teratoma test, sterility test.
• Whether you are starting with primary cells, tissue samples, or pluripotent stem cells, Ace Therapeutics can meet your stem cell expansion goals. The most important condition for the expansion of stem cells is the right culture conditions.

Ace Therapeutics has optimized the optimal culture conditions for different sources of stem cells and has established stable and standardized culture processes to ensure the scientific and reproducible generation and expansion of stem cells from different sources. Our aim is to ensure the yield and quality of your stem cell expansion. In addition, we also have an extensive and secure stem cell bank that can provide you with the stem cells you want.

Transplant Route Screening

For the development of stem cell therapies for stroke, an appropriate targeted intracerebral transplant route is critical. Traditional intracerebral injection routes or intracerebral transplantation of stem cells can lead to brain damage, there is a need to develop more appropriate intracerebral transplantation routes for the treatment of stroke. Ace Therapeutics has successfully established various stem cell transplant routes for the development of stem cell therapies for stroke, including but not limited to the intravenous route, intra-arterial route, intranasal route, intrathecal or intracerebroventricular route, and intracerebral route. We will select the appropriate transplant route for you based on your protocol and design.

Evaluation of The Role of Stem Cells in Stroke

After determining the cell type and transplantation route, we explore the effect of stem cells on stroke.

• Ace Therapeutics explores the effect of stem cells on the recovery of neurons with stroke injury by co-culturing stem cells with neurons and evaluates the effect in terms of neuronal activity, inflammatory response, neuronal mitochondrial function, and others.
• By transplanting stem cells into stroke model animals, we determined the therapeutic effect of stem cells on stroke by evaluating the infarct volume, neurological deficits, and neuroinflammation in the brain.
• We examined stem cell distribution, migration and homing, cell differentiation, and abnormal immune response to assess the role of candidate stem cells in stroke.

We offer custom stem development services for the treatment of stroke based on your experimental needs. If you would like to learn more about our services, please feel free to contact us.

1. Brown, J., et al. Bone marrow-derived ncs-01 cells advance a novel cell-based therapy for stroke. Int J Mol Sci, 2020. 21(8).
2. Diamandis, T.Borlongan, C. V. One, two, three steps toward for stroke. Stroke, 2015. 46(2): p. 588-591.